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Circadian metabolism is an emerging field aiming to elucidate the interconnected network between circadian biology and metabolism for better understanding of temporal organization of metabolism.

Time of eating is crucial to maintain the homeostasis of the body, in part through resetting the daily rhythms of organ physiology. It is generally thought that circadian-aligned night-time restricted feeding (NRF) synchronizes the circadian physiology with the center of biological rhythms in the brain (hypothalamus), whereas circadian-misaligned daytime-restricted feeding (DRF) disrupts the harmony within the body and increases the risks to obesity- and age-associated detriment to health, such as diabetes and cardiovascular disease. Recently, Xin et al. have reported that short-term DRF is beneficial to exercise performance in rodent models, the mechanistic target of which – Perilipin-5 – is regulated by exercise training in human muscle tissues.

CircaMetDB (Circadian Metabolism Multi-omics Profiles Data-Base) is humbly presented to you by the Center for Circadian Metabolism and Cardiovascular Disease (CircaMet-CVD) located in Department of Cardiovascular Medicine, Southwest Hospital, Chongqing, China.

1. CircaMetDB provides a database to inquire whether your gene(s) of interest is expressed in a circadian manner and reset by feed-fast cycle in mouse tissues, such as liver, heart, visceral adipose tissue (VAT), kidney, skeletal muscle, and anterior hypothalamus. (See “Search - mRNA” page)

2. Or to inquire whether a liver protein with/without any of its post-translational modification is circadian and entrained by time-restricted feeding. (See “Search - Proteome” page)

3. To inquire whether your favorite non-coding RNA, polar metabolite or lipid is circadian and entrained by time-restricted feeding. (See “Browse” page)

Rhythmicity statistics were assessed by MetaCycle, CircaCompare and RAIN algorithms. TRF, time-restricted feeding. NRF, denotes night/wake time-restricted feeding or active-phase feeding. DRF denotes day/sleep time-restricted feeding or rest-phase feeding.

Suggested Citations:

Transcriptomics and metabolomics/lipidomics profiling

[1] Xin H, Huang R, Zhou M, et al. Daytime-restricted feeding enhances running endurance without prior exercise in mice. Nat Metab. 2023;5:1236–1251. Available from: https://www.nature.com/articles/s42255-023-00826-7.

[2] Zhou M, Chen J, Huang R, et al. Circadian signatures of anterior hypothalamus in time-restricted feeding. F1000Research. 2022;11:1087. Available from: https://f1000research.com/articles/11-1087/v1.

[3] Li M-D. Clock-modulated checkpoints in time-restricted eating. Trends Mol Med. 2022;28:25–35. Available from: https://doi.org/10.1016/j.molmed.2021.10.006.

[4] Xin H, Deng F, Zhou M, et al. A multi-tissue multi-omics analysis reveals distinct kinetics in entrainment of diurnal transcriptomes by inverted feeding. iScience. 2021;24:102335. Available from: https://doi.org/10.1016/j.isci.2021.102335.

Proteomics profiling:

[1] Huang R, Chen J, Zhou M, et al. Multi-omics Profiling Reveals Rhythmic Liver Function Shaped by Meal Timing. Nat Comm. 2023; 14:6086. Available from: https://www.nature.com/articles/s41467-023-41759-9.

Resource:

CircaDB: Circadian Expression Profiles Data Base. http://circadb.hogeneschlab.org/

Nitecap: easy-to-use circadian and rhythmic analyses.  https://nitecap.org/